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New Nitric Oxide Treatment Eradicates Emerging 'Superbugs'
Durham, North Carolina

Novoclem Therapeutics, a biotech company focused on advancing nitric oxide therapies for the treatment of respiratory diseases, has announced that data from an in vitro study with BIOC51, a nitric oxide-releasing biopolymer being developed for the treatment of Pseudomonas aeruginosa infections in cystic fibrosis patients, will be presented at the 2017 ID Week conference in San Diego, California.

Novoclem's study, conducted by researchers at Southern Research Institute, demonstrated broad spectrum in vitro eradication of Gram-positive and Gram-negative multi drug resistant bacteria, including Methicillin-resistant Staphylococcus aureus (MRSA), Klebsiella pneumoniae and Pseudomonas aeruginosa. These bacteria have been identified by the Centers of Disease and Control Prevention (CDC) as rapidly spreading and severe public threats in infectious diseases due to the limited availability of new antibiotic treatments.

"Superbugs are a significant barrier to effectively treating the most severe infections. In fact, both the CDC and the World Health Organization have identified antibiotic-resistant bacteria as one of the most serious health threats we face," said Dr. Mark Schoenfisch, Professor of Chemistry at the University of North Carolina at Chapel Hill, co-inventor of the nitric oxide-releasing biopolymer, and Novoclem's Chief Scientific Officer. "The broad spectrum antibacterial action of nitric oxide and its short half-life in blood avoid systemic side effects, which make this technology highly attractive for treating drug-resistant bacteria."

About Novoclem Therapeutics, Inc.

Novoclem Therapeutics, Inc., a subsidiary of KNOW Bio, LLC, is an innovative, preclinical-stage pharmaceutical company focused on helping people who suffer from severe respiratory diseases to breath better and live life more fully. It is initially focused on developing a nitric oxide based treatment for people living with cystic fibrosis and infected with Pseudomonas aeruginosa. The company anticipates submitting an Investigational New Drug application and initiating First in Human clinical trials in 2018. More info available at www.novoclem.com.

About KNOW Bio LLC KNOW Bio, LLC, is a life science company committed to improving and extending people's lives by advancing the development and commercialization of its drug and device pipeline through wholly or majority owned subsidiary companies. Each of the subsidiaries is focused on specific therapeutic applications where nitric oxide can provide meaningful health benefit.

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