Winter Issue January 2025
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Better Living Through Well Being

Enthusiasm, interest and pursuit of scientific and medical research on the psychiatric application of psychedelic compounds has exploded in recent years such that this current phase is declared a “renaissance period for psychedelic research.” Published clinical trials now exceed a thousand with the largest representation being those participating in psilocybin studies.

Psilocybin is a naturally recurring compound derived from fungi with mind-altering qualities similar to those of LSD and mescaline. Most study participants experience profound alterations in perception, emotions, and sense of self, often including experiences that are felt to be of great personal and spiritual significance. Because the drug raises blood pressure and heart rate and can cause incapacitating and sometimes overwhelming psychological effects, researchers caution that it should only be used in controlled settings and in conjunction with medical and psychological evaluation and careful preparation.

The January 2025 issue of The American Journal of Psychiatry is titled “Special Issue on Psychedelics.” The authors provide an overview of the current state of research regarding psychedelic treatments for psychiatric disorders. This issue of the Journal addresses many of the ongoing challenges and looming questions in the field of psychiatric psychedelic research and treatment. These include issues relevant to basic pharmacology and effects on neural circuits, evidence of clinical efficacy, methodological challenges/limitations of existing research, and factors pertaining to public health and policy considerations.

Though the field has grown tremendously in the past 30 years, there are still numerous obstacles to overcome before psychedelics might one day become mainstream psychiatric treatments.

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Unlikely Collaborators is a nonprofit foundation that exists to help people resolve conflict by making them aware of and helping them work with their own Perception Box. The foundation established a Spark grant program in 2024 intended to form collaborations between organizations and individuals committed to disarming societal and institutional issues in every far corner of the planet. The collaboration is carried out through seemingly unlikely ways as a result of integrating the lens of the Perception Box.

Perception Box is a metaphor for our subjective experience of reality. It’s an invisible ever-present mental box each of us lives inside that colors and shapes everything we experience. This box tends to inhibit our ability to understand one another and ourselves, which can leave us feeling fearful, disconnected and isolated. By going inward and questioning the beliefs that hold us back, we learn to see them for what they are -- often moments of confusion we never unpacked.

Thus the walls of our own Perception Box are expanded, helping us see beyond our beliefs to participate more fully in the beauty of life.

Unlikely Collaborators has awarded a Spark grant to fund an innovative research collaboration between the Institute for Advanced Consciousness Studies (IACS), Andrew Holecek, and Sky Cave Retreats. This groundbreaking project aims to explore the intersection of consciousness, mental well-being, and the monumental potential of dark retreats, which involve spending time in complete darkness to facilitate profound shifts in perception and consciousness.

This collaboration brings together cutting-edge consciousness research and timeless contemplative practices to be conducted at Sky Cave Retreats, and promises to break new ground in characterizing deep states of consciousness induced by prolonged dark exposure and how such non-pharmacological experiences can drive personal and societal transformation. The study will utilize EEG and peripheral measurements to provide the first comprehensive scientific characterization of the rapid psychospiritual shifts brought about by dark retreats. It provides a unique path to investigate non-pharmacological routes to transformative states at a time when psychedelic research dominates discussions of consciousness exploration.

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An expert workgroup representing primary and specialty care has developed new guidelines for comprehensive evaluation of patients who may have cognitive impairment or dementia due to Alzheimer’s disease or a related disease. The current guidelines for a comprehensive evaluation process are over 20 years old. Highlights of the new guidelines are published in a special issue of Alzheimer’s and Dementia: The Journal of the Alzheimer’s Association.

These guidelines do not propose diagnostic or staging criteria for these diseases, which continue to evolve. Rather, they provide a framework for a high-quality process tailored to each individual patient that enables clinicians to establish a diagnostic formulation. Some details for the guidelines will likely require modification as new tools and biomarkers become sufficiently validated for appropriate clinical use in real-world practice. The workgroup leveraged best evidence and practices to empower persons with memory of thinking symptoms or concerns and their loved ones, clinicians, and health systems to engage in a person-centered process that will enhance knowledge, appreciation and autonomy for the person with a potential illness and facilitate doing what is right for them.

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Other articles of interest in this TMIS eNewsletter for Winter 2025:

* Global reforestation organization collaborates with electrical industry leader to plant 10,000 trees across the United States.

* Fully solar-driven, autonomous atmospheric water generator has been developed using advanced aerogels.

* Seasonal self-discovery guide provides practical framework for creating a meaningful life in a world of shifting expectations.

* Company unveils big topics of global optimism driven by entertainment, AI and healthcare.

* “Social Connection in a Modern World” report reveals scale of the loneliness crisis in America’s loneliness epidemic.

* National Program of All-Inclusive Care for the Elderly (PACE) takes major step in changing how we provide care for seniors.

* New discovery guides future research into eye and balance disorders among newborns and young children.

* Americans are projected to spend over $12 billion less on gasoline in 2025 compared to 2024.

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I am grateful to be in a collaborative business with many talented and skilled professionals. Your feedback is always welcome.

- Mary Michele McLaughlin


From the Front Page of TMIS News
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Psychedelic Drug Therapy May Address Mental Health Concerns in People with Cancer and Addiction
New York, New York

One or two doses of psilocybin, a compound found in psychedelic mushrooms, may improve the mental health of cancer patients when accompanied by psychotherapy, a new report suggests. A second new study found that treatment with psilocybin resulted in lasting, positive personality changes in patients with alcohol use disorder.

The first report's findings were published online Oct. 7 in the journal Nature Mental Health, and the second published online Jan. 1 in a special edition of The American Journal of Psychiatry focused on psilocybin research.

In the first study, a team of experts at NYU Langone Health found that psilocybin accompanied by psychotherapy significantly reduced anxiety, depression, obsessive thoughts, anger toward others, and physical symptoms associated with psychological distress, with improvements lasting up to six months.

Full Story

Unlikely Collaborators Awards Spark Grant to Support Transformative Consciousness Studies Project
Los Angeles, California

Unlikely Collaborators has awarded a Spark grant to fund an innovative research collaboration between The Institute for Advanced Consciousness Studies (IACS), Andrew Holecek, and Sky Cave Retreats. This groundbreaking and cutting-edge project aims to explore the intersection of consciousness, mental well-being, and deep retreat experiences, reimagining the narratives surrounding inner transformation and human potential.

The Spark grants, launched in 2024, support bold, collaborative projects that integrate the Perception Box lens to reimagine narratives and create meaningful change. Each grant prioritizes 501(c)(3) partnerships between organizations and individuals who have not worked together before, fostering innovation and unexpected synergy.

Unlikely Collaborators is a mission-driven nonprofit committed to transforming narratives that limit individuals, communities, and societies. The organization promotes self-awareness and mutual understanding by helping individuals gain insight into and agency over their Perception Box -- a concept developed by Elizabeth R. Koch. Perception Box represents the internal beliefs, experiences, and biases that shape how individuals view the world and engage with others. Through grants, partnerships, and transformative initiatives, Unlikely Collaborators supports organizations that help individuals and communities untangle limiting stories and foster meaningful change.

The research project funded by this Spark grant will focus on the monumental potential of dark retreats, an ancient contemplative practice gaining modern attention. Dark retreats involve spending time in complete darkness to facilitate profound shifts in perception and consciousness. NBA star Rudy Gobert described his experience as "meditation times a thousand." The practice places participants in a dark environment that intentionally disrupts routine habits and perceptions, creating a unique contrast medium that allows practitioners to see and feel things normally lost in the light and busyness of daily life.

Full Story

New Clinical Practice Guideline on the Process for Diagnosing Alzheimer's Disease or a Related Form of Cognitive Impairment or Dementia
Sun City, Arizona

We have entered a new era of improved and emerging biologically-based diagnostic biomarkers for Alzheimer's disease (AD) and AD-related neurodegenerative disorders (ADRD) that are rapidly impacting evaluation and care paradigms in every clinical setting: primary care, specialty care and dementia subspecialty care.

A comprehensive evaluation includes setting goals in partnership with the patient and usually a care partner; obtaining information about the patient's risk profile for AD or a related disease (e.g., age, family history of dementia, hypertension, smoking); describing the history of symptoms and their impact on daily life; evaluating the patient's ability to perform tests of thinking abilities; and obtaining a brain MRI or CT scan along with laboratory tests for conditions that may contribute to cognitive impairment. The integration of new brain scans, spinal fluid tests, or other specialized tests into this comprehensive evaluation will add critical value to the diagnostic formulation and care plan for persons in whom there is a clinical concern for AD or an ADRD.

A special issue of the journal Alzheimer's & Dementia: The Journal of the Alzheimer's Association highlights the new Alzheimer's Association Clinical Practice Guideline for the Diagnostic Evaluation, Testing, Counseling and Disclosure of Suspected Alzheimer's Disease and Related Disorders (DETeCD-ADRD CPG) that summarizes the process of diagnostic evaluation and disclosure for persons suspected of potentially having cognitive-behavioral impairment due to AD or ADRD. ADRDs include Lewy Body Disease, Frontotemporal Lobar Degeneration, Vascular Cognitive Impairment and Dementia (VCID), and a host of other diseases and conditions that may cause or substantially contribute to cognitive-behavioral impairment. Similar American guidelines are more than 20 years old and aimed at specialists or dementia subspecialists.

Full Story

TESSAN Teams Up with One Tree Planted to Launch Global Tree Planting Initiative
Shelburne, Vermont

The leading charging solution provider TESSAN has announced a new initiative to plant 10,000 trees across the United States and beyond. Through its collaboration with One Tree Planted, a non-profit organization dedicated to global reforestation, TESSAN showcases its long-term commitment to environmental sustainability and climate action as a climate-friendly brand.

Alex, the CEO of TESSAN, emphasized the brand's dedication to fostering meaningful connections, not only between people and places but also between humanity and the planet. "We are excited to join One Tree Planted to make contribution to global reforestation," said Alex. "Our journey at TESSAN is not just about creating innovative charging solutions. It is about establishing meaningful connections, and planting trees is one of the most direct actions to forge this bond. Through our collaboration with One Tree Planted, we aim to strengthen our connection with the Earth and encourage travelers using our products to seize every opportunity to engage in climate action, truly exploring the world and building a green connection with the planet."

One Tree Planted is committed to global tree planting and forest restoration efforts. The organization operates with a mission to engage transparently and effectively in worldwide forest conservation by planting one tree for every dollar donated. Their initiatives span the globe, striving to enhance ecosystem sustainability.

Full Story

Grabbing water from the air: NUS researchers develop advanced aerogels for autonomous atmospheric water harvesting
Denver, Colorado

The world is on the brink of a freshwater crisis. Estimations indicate that by 2025, half of the world's population may reside in areas facing water scarcity. In response to this challenge, researchers from the National University of Singapore (NUS) have developed a novel aerogel designed to enhance the efficiency of atmospheric water harvesting.

This development, led by Associate Professor TAN Swee Ching from the Department of Materials Science and Engineering under the College of Design and Engineering at NUS, offers a practical solution to the pressing issue of freshwater scarcity, particularly in arid regions.

The aerogel is capable of absorbing moisture from the air up to about 5.5 times its weight, maintaining its performance across a wide range of humidity levels, and effective even in conditions as low as 20 per cent relative humidity, making it suitable for diverse environments. Demonstrating the aerogel's applicability, the research team has integrated it into a solar-driven, autonomous atmospheric water generator that efficiently collects and releases freshwater without requiring external energy sources.

Full Story

Redefining Success: How Small Intentional Steps Help Us Adapt and Thrive in Changing Times
Rotterdam, Netherlands

In a remarkable development for cancer research, patients with advanced-stage cancer have benefited from SUPLEXA, a personalized treatment that trains the patient's own immune cells to fight cancer.

Each new year begins with hopeful resolutions--a chance to reset, reflect, and pursue a more purposeful life. Yet by Blue Monday--the third Monday of January and the so-called saddest day of the year--many feel the weight of unmet aspirations. Studies reveal nearly 80% of New Year's resolutions fail by early February, leaving individuals overwhelmed and disconnected.

This failure isn't just about personal shortcomings. In a world of economic uncertainty, societal shifts, and relentless digital noise, traditional strategies like willpower alone are no longer enough. As pressures mount, more individuals are actively looking to step away from the demands of modern life and seek tools and support to create lives rooted in clarity, resilience, and intentional choices.

Recognizing this need, Glimmery Moments introduces the Seasonal Self-Discovery Guide--a thoughtfully crafted tool blending behavioral science and mindfulness. Designed to anchor progress in small, intentional steps, the guide empowers individuals to build resilience, set achievable goals, and embrace a life aligned with their values.

Full Story

The State of Global Optimism Revealed in New Survey
Seoul, South Korea

According to the latest research by LG Electronics (LG), 48 percent of consumers say they are more optimistic now than they were compared to six months ago.

The survey, conducted across 16 markets, provides extensive data on global optimism, its drivers and the demographics that feel the most optimistic and happy. The global average optimism score is 7.49/10. France, the UK and Australia were revealed to be among the least optimistic countries, scoring 14.5 percent below the average. Conversely, Saudi Arabia (12 percent above), India (10.8 percent above) and the UAE (8.1 percent above) were the most optimistic. Consumers were most optimistic about their personal growth and development (69 percent) and family dynamics (66 percent), but least optimistic about their finances.

Full Story

New Report from Sunny Further Reveals America's Loneliness Epidemic--and How to Fix It
Dallas, Texas

Sunny, a nonprofit dedicated to fostering meaningful social connection, is breaking new ground with its latest report, Social Connection in the Modern World. Leveraging data from the 2024 U.S. Census Bureau's Household Pulse Survey, this analysis shines a light on the stark realities of loneliness and isolation in America today--offering valuable insights and practical actions for building connection.

"With our custom analysis, we can see the scale of the loneliness crisis with incredible clarity," says Heather Liu Leary, PhD, co-author of the report. "This remarkable data set doesn't just describe the problem; it points us directly to where we might uncover effective solutions."

Full Story

Bill Provides Veterans With Increased Access to the Program of All-Inclusive Care for the Elderly and Greatly Improves Their Lives
Washington, D.C

The National PACE Association (NPA) has said that President Biden's signing of the Senator Elizabeth Dole 21st Century Veterans Healthcare and Benefits Improvement Act gives veterans increased access to the Program of All-Inclusive Care for the Elderly (PACE) across the nation demonstrates an innovative model of care for all seniors.

"This bill will dramatically expand the options available to our veterans who want to age in place," said Shawn Bloom, president and CEO of NPA. "Moving forward, there are a myriad of additional actions that Congress can take to easily implement PACE for hundreds of thousands of additional seniors and their families who would benefit from PACE."

PACE is a Medicare and Medicaid program that allows seniors with a nursing home-level of need to be cared for while remaining living in their own homes. PACE reduces costs for state Medicaid budgets when compared to nursing homes.

Providing care at home and in the community not only enhances the quality of life for veterans, their families and their caregivers, but also reduces VA health expenditures. Generally, the cost of HCBS is notably less than institutional care. Further, the VA has found that the use of HCBS creates additional savings by either delaying admission to a nursing home or avoiding such an admission altogether as well as lowering the risk of preventable hospitalizations.

Full Story

Newborn Brain Circuit Stabilizes Gaze
New York, New York

An ancient brain circuit, which enables the eyes to reflexively rotate up as the body tilts down, tunes itself early in life as an animal develops, a new study finds. Led by researchers at NYU Grossman School of Medicine, the study revolves around how vertebrates, which includes humans and animals spanning evolution from primitive fish to mammals, stabilize their gaze as they move. To do so they use a brain circuit that turns any shifts in orientation sensed by the balance (vestibular) system in their ears into an instant counter-movement by their eyes.

Called the vestibulo-ocular reflex, the circuit enables the stable perception of surroundings. When it is broken -- by trauma, stroke, or a genetic condition -- a person may feel like the world bounces around every time their head or body moves. In adult vertebrates, it and other brain circuits are tuned by feedback from the senses (vision and balance organs). The current study authors were surprised to find that, in contrast, sensory input was not necessary for maturation of the reflex circuit in newborns.

Published online January 2 in the journal Science, the study featured experiments done in zebrafish larvae, which have a similar gaze stabilizing reflex to the one in humans. Further, zebrafish are transparent, so researchers literally watched brain cells called neurons mature to understand the changes that let a newborn fish first rotate its eyes up appropriately as its body tilts down (or its eyes down as its body tilts up).

"Discovering how vestibular reflexes come to be may help us find new ways to counter pathologies that affect balance or eye movements," says study senior author David Schoppik, PhD, associate professor in the Departments of Otolaryngology--Head & Neck Surgery, Neuroscience & Physiology, and the Neuroscience Institute, at NYU Langone Health.

Full Story

2025 To Bring Third Straight Yearly Decline in Gas Prices, Though Risks Emerge
Dallas, Texas

GasBuddy, a PDI company, has released its 2025 Fuel Price Outlook, forecasting a third consecutive year of lower gas and diesel prices. The outlook highlights key trends in gasoline and diesel prices utilizing specific inputs, potential impacts on production, supply and demand changes and a change in leadership in Washington.

GasBuddy projects that the yearly national average for gasoline in 2025 will decline to $3.22 per gallon, down from $3.33 in 2024 and significantly below the record highs of 2022. This decline represents continued relief for American drivers, but comes amid emerging uncertainties surrounding geopolitical tensions, potential tariffs and a change in energy policies that add risk to this year's forecast.

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January 9, 1951 – November 19, 2023

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